In practice and despite Anfinsen’s dogma. the refolding of recombinant multiple SS-bonded proteins is famously difficult because misfolded species with non-native SS-bonds appear upon the oxidization of their cysteine residues. On the other hand. single SS-bond proteins are thought to be simple to refold because their cysteines have only one SS-bond partner. https://www.spidertattooz.com/OPI-Infinite-Shine-All-Your-Dreams-in-Vending-Machines-ISLT84-p27376/