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Deroyal finger spring

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The highly stereoselective bioreduction of ethyl cyclohexanone-2-carboxylate (1) on a kilogram scale is described. Ethyl(1S. 2S)-trans-2-hydroxycyclohexane carboxylate (2) was prepared in 56% yield with a diastereomeric ratio (dr) of 99:1 and an enantiomeric ratio (er) of 99. 5:0. https://www.roneverhart.com/DeRoyal-LMB-Spring-Finger-Extension-Assist/
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